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Pterosin B

CAS No. 34175-96-7

Pterosin B( 2R)-Pterosin B )

Catalog No. M14162 CAS No. 34175-96-7

Pterosin B is a potent and specific SIK3 signaling inhibitor that suppresses SIK3 downstream cascades by up-regulating the phosphorylation levels in the SIK3 C-terminal regulatory domain.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Pterosin B
  • Note
    Research use only, not for human use.
  • Brief Description
    Pterosin B is a potent and specific SIK3 signaling inhibitor that suppresses SIK3 downstream cascades by up-regulating the phosphorylation levels in the SIK3 C-terminal regulatory domain.
  • Description
    Pterosin B is a potent and specific SIK3 signaling inhibitor that suppresses SIK3 downstream cascades by up-regulating the phosphorylation levels in the SIK3 C-terminal regulatory domain; shows no effect on up-regulation of MEF2 and down-regulation of CRTC2 activities by SIK1 or SIK2; promotes glucose production by up-regulating gluconeogenic gene expression in mouse hepatoma AML-12 cells, decreases the glycogen content and stimulates an association between PHKG2 and SIK3.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    2R)-Pterosin B
  • Pathway
    Autophagy
  • Target
    SIK
  • Recptor
    SIK
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    34175-96-7
  • Formula Weight
    218.296
  • Molecular Formula
    C14H18O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (1145.27 mM)
  • SMILES
    CC1CC2=C(C1=O)C(=C(C(=C2)C)CCO)C
  • Chemical Name
    1H-Inden-1-one, 2,3-dihydro-6-(2-hydroxyethyl)-2,5,7-trimethyl-, (R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Itoh Y, et al. J Biol Chem. 2015 Jul 17;290(29):17879-93. 2. Yahara Y, et al. Nat Commun. 2016 Mar 24;7:10959.
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