Pterosin B

CAS No. 34175-96-7

Pterosin B( 2R)-Pterosin B )

Catalog No. M14162 CAS No. 34175-96-7

Pterosin B is a potent and specific SIK3 signaling inhibitor that suppresses SIK3 downstream cascades by up-regulating the phosphorylation levels in the SIK3 C-terminal regulatory domain.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 314 In Stock
50MG 1188 In Stock
100MG 1791 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Pterosin B
  • Note
    Research use only, not for human use.
  • Brief Description
    Pterosin B is a potent and specific SIK3 signaling inhibitor that suppresses SIK3 downstream cascades by up-regulating the phosphorylation levels in the SIK3 C-terminal regulatory domain.
  • Description
    Pterosin B is a potent and specific SIK3 signaling inhibitor that suppresses SIK3 downstream cascades by up-regulating the phosphorylation levels in the SIK3 C-terminal regulatory domain; shows no effect on up-regulation of MEF2 and down-regulation of CRTC2 activities by SIK1 or SIK2; promotes glucose production by up-regulating gluconeogenic gene expression in mouse hepatoma AML-12 cells, decreases the glycogen content and stimulates an association between PHKG2 and SIK3.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    2R)-Pterosin B
  • Pathway
    Autophagy
  • Target
    SIK
  • Recptor
    SIK
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    34175-96-7
  • Formula Weight
    218.296
  • Molecular Formula
    C14H18O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (1145.27 mM)
  • SMILES
    CC1CC2=C(C1=O)C(=C(C(=C2)C)CCO)C
  • Chemical Name
    1H-Inden-1-one, 2,3-dihydro-6-(2-hydroxyethyl)-2,5,7-trimethyl-, (R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Itoh Y, et al. J Biol Chem. 2015 Jul 17;290(29):17879-93. 2. Yahara Y, et al. Nat Commun. 2016 Mar 24;7:10959.
molnova catalog
related products
  • Dp44mT

    Dp44mT, a effective iron chelator, has selective antitumor activity.

  • WH-4-025

    WH-4-025 is a?Salt-inducible kinase (SIK)?inhibitor.

  • Pterosin B

    Pterosin B is a potent and specific SIK3 signaling inhibitor that suppresses SIK3 downstream cascades by up-regulating the phosphorylation levels in the SIK3 C-terminal regulatory domain.