Pterosin B( 2R)-Pterosin B )

Catalog No. M14162 CAS No. 34175-96-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Pterosin B
Note

Research use only, not for human use.
Brief Description

Pterosin B is a potent and specific SIK3 signaling inhibitor that suppresses SIK3 downstream cascades by up-regulating the phosphorylation levels in the SIK3 C-terminal regulatory domain.
Description

Pterosin B is a potent and specific SIK3 signaling inhibitor that suppresses SIK3 downstream cascades by up-regulating the phosphorylation levels in the SIK3 C-terminal regulatory domain; shows no effect on up-regulation of MEF2 and down-regulation of CRTC2 activities by SIK1 or SIK2; promotes glucose production by up-regulating gluconeogenic gene expression in mouse hepatoma AML-12 cells, decreases the glycogen content and stimulates an association between PHKG2 and SIK3.
In Vitro

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In Vivo

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Synonyms

2R)-Pterosin B
Pathway

Autophagy
Target

SIK
Recptor

SIK
Research Area

Other Indications
Indication

——

CAS Number

34175-96-7
Formula Weight

218.296
Molecular Formula

C14H18O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (1145.27 mM)
SMILES

CC1CC2=C(C1=O)C(=C(C(=C2)C)CCO)C
Chemical Name

1H-Inden-1-one, 2,3-dihydro-6-(2-hydroxyethyl)-2,5,7-trimethyl-, (R)-

1. Itoh Y, et al. J Biol Chem. 2015 Jul 17;290(29):17879-93. 2. Yahara Y, et al. Nat Commun. 2016 Mar 24;7:10959.

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